“Over 9 months, we wrote over 70,000 lines of infrastructure code, and the goal was to make it reusable and keep the architecture clean.” Then, in August 2018, Tipico migrated in just 1 week without impacting customers. “We didn’t lift and shift,” says Michał Szychowski, cloud architect at Tipico. Tipico was operating with a legacy on-premises database in Amsterdam until 2017, when it decided to migrate to AWS. Tipico offers safe, secure digital and mobile betting entertainment across 30 sports-mainly soccer and tennis-to about seven million customers. The company also optimized time, achieved scalability, and gained the ability to quickly replicate to new markets. Using AWS Outposts, Tipico was able to effectively meet its data residency requirements without the overhead of setting up on-premises infrastructure or rewriting its software stack. The company turned to AWS Outposts, a fully managed service that offers the same AWS infrastructure, services, APIs, and tools to virtually any data center, colocation space, or on-premises facility. To operate in the United States and comply with regulations, it would have to deploy infrastructure in colocation facilities and use different tools and services to run its application than it uses in the cloud. Tipico had recently migrated its legacy on-premises applications to AWS. US regulations require that online bookmakers maintain their user data on premises within state boundaries. Tipico, an international sports bookmaker with a large market share in Germany, wanted to enter the US market to expand its business.
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In this study, we sought to test the hypothesis that inhalable poly(lactic-co-glycolic acid) (PLGA) particles of sildenafil prolong the release of the drug, produce pulmonary specific vasodilation, reduce the systemic exposure of the drug, and may be used as an alternative to oral sildenafil in the treatment of PAH. The practice of treating PAH patients with oral or intravenous sildenafil suffers from the limitations of short dosing intervals, peripheral vasodilation, unwanted side effects, and restricted use in pediatric patients. Rashid, Jahidur Patel, Brijeshkumar Nozik-Grayck, Eva McMurtry, Ivan F Stenmark, Kurt R Ahsan, Fakhrul Inhaled sildenafil as an alternative to oral sildenafil in the treatment of pulmonary arterial hypertension (PAH). System Requirements and Technical Details
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